DEFI - Education, Training, and Research Department is part of Centro Hospitalar Universitário do Porto, one of the major hospitals of the Portuguese National Health System. The hospital campus is located in the historical city center.

DEFI is organized in four areas, bringing together Clinical Research, Education and Training Center, Library and Documentation, and Cultural Heritage and Museum.

Established in 2007, DEFI is the driving, support, and monitoring structure of clinical research. Its duties include centralizing studies and research projects, coordinating clinical trials, and editing scientific reports. Through DEFI, the Hospital manages research funds and supports project applications for funding.